Adenosine Deaminase Acting on RNA (ADAR1) Suppresses the Induction
نویسندگان
چکیده
4 5 Zhiqun Li, Kristina M. Okonski, and Charles E. Samuel 6 7 8 Department of Molecular, Cellular and Developmental Biology, University of California, 9 Santa Barbara, California 93106 10 11 12 13 14 Word count for abstract: 248 Word count for text: 5099 15 16 Running Title: ADAR1-mediated suppression of IFN induction by measles virus 17
منابع مشابه
Adenosine Deaminase Acting on RNA-1 (ADAR1) Inhibits HIV-1 Replication in Human Alveolar Macrophages
While exploring the effects of aerosol IFN-γ treatment in HIV-1/tuberculosis co-infected patients, we observed A to G mutations in HIV-1 envelope sequences derived from bronchoalveolar lavage (BAL) of aerosol IFN-γ-treated patients and induction of adenosine deaminase acting on RNA 1 (ADAR1) in the BAL cells. IFN-γ induced ADAR1 expression in monocyte-derived macrophages (MDM) but not T cells. ...
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متن کاملExpression of interferon-inducible RNA adenosine deaminase ADAR1 during pathogen infection and mouse embryo development involves tissue-selective promoter utilization and alternative splicing.
ADAR1 (adenosine deaminase acting on RNA) is widely expressed in adult mammals and has a critical role during embryogenesis. Two size forms of ADAR1 are known that possess adenosine-to-inosine editing activity: an interferon (IFN)-inducible approximately 150-kDa protein and a constitutively expressed N-terminally truncated approximately 110-kDa protein. We defined the structure of the 5'-flanki...
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تاریخ انتشار 2012